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Pickart originally isolated GHK as the "growth factor" responsible for restoring proliferation to liver cells in older-donor plasma, and the copper-binding role was recognized shortly afterward as the molecular basis for many of the activities attributed to the peptide

Results Targeting functional GCL to mitochondria decreases ROS To direct -glutamylcysteine synthesis to mitochondria, the full-length complementary DNA encoding the catalytic GCL subunit was fused with the mitochondrial-targeting signal of ornithine transcarbamylase

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PMID: 39921384

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